PE-22-28
Spadin-derived peptide studied for mood and neuroplasticity.
For research purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm these products will be used for legitimate research purposes.
About PE-22-28
PE-22-28 is a synthetic analogue of spadin that blocks the TREK-1 potassium channel, a target linked to depression. It is researched for rapid mood support and enhanced neuroplasticity, with interest in fast-acting antidepressant-like effects and neural regeneration.
Key Benefits
- Blocks the TREK-1 channel linked to mood
- Studied for rapid mood support
- Promotes neuroplasticity
- Interest in neural regeneration
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Category Ratings
How to Take
Common Side Effects
- Injection site reactions
- Headache
- Mild fatigue
Legal & Regulatory Status
Research use only. Not FDA-approved. Antidepressant (TREK-1) effects are preclinical (rodent) only; no human data.
Safety and regulatory details for FDA-approved compounds are drawn from the official product label via openFDA; clinical development status reflects ClinicalTrials.gov. This information is provided for research reference, is not endorsed by the FDA, and may not be complete or current.
Research & Sources
Sources are selected for reliability (peer-reviewed literature, openFDA, ClinicalTrials.gov) but this is a research summary, not medical advice, and may not be exhaustive.
Prices at quality-checked sources · as of July 2026 (3 weeks ago)
- 8mg $67.1710mg $84.09
Observed on each vendor’s public listing — see how these sources are vetted. Peptide Concierge doesn’t sell peptides and isn’t affiliated with any vendor; confirm current pricing at the source.
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