PAL-GHK (Palmitoyl Tripeptide-1)
Palmitoylated GHK — the same tripeptide as GHK-Cu, without the copper.
For research purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm these products will be used for legitimate research purposes.
About PAL-GHK (Palmitoyl Tripeptide-1)
PAL-GHK is the glycyl-histidyl-lysine tripeptide with a palmitoyl chain attached, best known as one half of the Matrixyl 3000 combination. It is worth being precise about how it relates to GHK-Cu, which is already in this catalog: both share the same GHK core, but GHK-Cu is the copper complex — and much of GHK's documented biology, particularly its antioxidant and wound-signalling activity, is attributed to the copper it carries. PAL-GHK swaps that copper for a fatty-acid tail chosen to improve skin penetration. They are related compounds with meaningfully different properties, not interchangeable versions of the same thing. Evidence specific to PAL-GHK is much thinner than for either GHK-Cu or Matrixyl. It appears in the cosmetic literature mainly as a component of combination products and in general reviews of palmitoylated cosmetic peptides, rather than as the subject of its own controlled trial.
Key Benefits
- Palmitoylated for better skin penetration than unmodified GHK
- One component of the widely used Matrixyl 3000 combination
- Shares the well-studied GHK tripeptide core
Set a goal (top of the page) to see how PAL-GHK (Palmitoyl Tripeptide-1) scores against it, and what the better-evidenced alternatives are.
Category Ratings
How to Take
Common Side Effects
- Contact irritation or sensitivity possible
- Poorly characterised on its own — most data covers combination products
- Not evaluated for injection
Legal & Regulatory Status
Sold as a cosmetic ingredient and as a research chemical; not a drug and not FDA-approved.
Safety and regulatory details for FDA-approved compounds are drawn from the official product label via openFDA; clinical development status reflects ClinicalTrials.gov. This information is provided for research reference, is not endorsed by the FDA, and may not be complete or current.
Research & Sources
- Novel palmitoyl pentapeptides: self-assembly, collagen stimulation, antioxidant activity (PMC13063098)
- Usage of synthetic peptides in cosmetics — covers palmitoyl tripeptide variants and penetration limits (PMC8400021)
Sources are selected for reliability (peer-reviewed literature, openFDA, ClinicalTrials.gov) but this is a research summary, not medical advice, and may not be exhaustive.
Prices at quality-checked sources · as of August 2026 (8 days ago)
- 10mg $45.87
Observed on each vendor’s public listing — see how these sources are vetted. Peptide Concierge doesn’t sell peptides and isn’t affiliated with any vendor; confirm current pricing at the source.
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