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MOTS-c

Activate metabolic pathways and enhance cellular energy production.

Preclinical evidenceEvidence comes from cell-culture and/or animal studies only. Effects have not been demonstrated in humans.

For research purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm these products will be used for legitimate research purposes.

About MOTS-c

MOTS-c is a mitochondrial-derived peptide encoded in the 12S rRNA gene of mitochondrial DNA. It regulates metabolic homeostasis by activating the AMPK pathway, enhancing glucose uptake and fatty acid oxidation. It is sometimes called an 'exercise mimetic' because it activates many of the same metabolic pathways as physical exercise.

Key Benefits

  • Activates AMPK metabolic pathway
  • Enhances glucose uptake and utilization
  • Promotes fatty acid oxidation
  • Mimics exercise-induced metabolic benefits

Set a goal (top of the page) to see how MOTS-c scores against it, and what the better-evidenced alternatives are.

Category Ratings

Muscle & Strength
Mild
Fat Loss
Mild
Recovery
Mild
Skin & Anti-Aging
N/A
Sleep
Minimal
Cognitive
Minimal
Immune
Mild
Longevity
Mild
Bone & Hormonal
N/A

How to Take

Injection

Subcutaneous injection into abdominal fat or thigh, preferably before exercise

Common Side Effects

  • Injection site reactions
  • Mild nausea
  • Transient fatigue
  • Temporary muscle soreness

Legal & Regulatory Status

Research use only. Not FDA-approved. Metabolic/exercise effects are preclinical (mice); human data is observational, not interventional.

Safety and regulatory details for FDA-approved compounds are drawn from the official product label via openFDA; clinical development status reflects ClinicalTrials.gov. This information is provided for research reference, is not endorsed by the FDA, and may not be complete or current.

Research & Sources

Preclinical evidenceEvidence comes from cell-culture and/or animal studies only. Effects have not been demonstrated in humans.

Sources are selected for reliability (peer-reviewed literature, openFDA, ClinicalTrials.gov) but this is a research summary, not medical advice, and may not be exhaustive.

MOTS-c

Prices at quality-checked sources · as of August 2026 (3 weeks ago)

Observed on each vendor’s public listing — see how these sources are vetted. Peptide Concierge doesn’t sell peptides and isn’t affiliated with any vendor; confirm current pricing at the source.

CategoryWeight Management
Formsinjectable

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