MGF (Mechano Growth Factor)
IGF-1 splice variant the body produces in response to muscle damage.
For research purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm these products will be used for legitimate research purposes.
About MGF (Mechano Growth Factor)
Mechano Growth Factor is IGF-1Ec, an alternative splice variant of the IGF-1 gene that human skeletal muscle upregulates after mechanical loading or damage. Its biology in humans is real and measurable: resistance exercise significantly increases MGF mRNA in young muscle, though notably not in elderly muscle (aged 70-82), which is one of the more interesting findings about it. The important distinction is that this is evidence about MGF the body makes, not evidence about injecting MGF — no human trial has administered the synthetic peptide. Animal work has shown effects on motoneuron survival and muscle function, and its native half-life in circulation is very short.
Key Benefits
- The splice variant human muscle actually produces after loading
- Upregulation after resistance exercise confirmed in human biopsies
- Studied for local rather than systemic signalling
- Effects on motoneuron survival shown in animal models
Set a goal (top of the page) to see how MGF (Mechano Growth Factor) scores against it, and what the better-evidenced alternatives are.
Category Ratings
How to Take
Common Side Effects
- Injection site irritation
- Localised swelling
- Theoretical risk of unregulated tissue growth with prolonged use
- Effects in humans from injection are uncharacterised
Legal & Regulatory Status
Research use only. Not FDA-approved. Human evidence describes endogenous MGF expression, not administration of the synthetic peptide — no clinical trial has injected it.
Safety and regulatory details for FDA-approved compounds are drawn from the official product label via openFDA; clinical development status reflects ClinicalTrials.gov. This information is provided for research reference, is not endorsed by the FDA, and may not be complete or current.
Research & Sources
- IGF-I splice variant expression in young vs old human muscle after resistance exercise (PMC2342624)
- Mechano-Growth Factor: an important cog or a loose screw in the repair machinery? — critical review (PMC3485521)
- MGF rescues motoneurons and improves muscle function in SOD1(G93A) mice — animal study (PMID 19038252)
- IGF-1 Ec/MGF — splice variant within the growth plate (PMC3795771)
Sources are selected for reliability (peer-reviewed literature, openFDA, ClinicalTrials.gov) but this is a research summary, not medical advice, and may not be exhaustive.
Prices at quality-checked sources · as of August 2026 (8 days ago)
- 10mg $143.09
Observed on each vendor’s public listing — see how these sources are vetted. Peptide Concierge doesn’t sell peptides and isn’t affiliated with any vendor; confirm current pricing at the source.
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