GHRP-6
First-generation GH secretagogue notable for pronounced appetite stimulation.
For research purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm these products will be used for legitimate research purposes.
About GHRP-6
GHRP-6 is a hexapeptide ghrelin-receptor agonist and one of the earliest GH secretagogues characterised in humans. Its distinguishing feature is appetite: it activates the hypothalamic NPY/AgRP neurons that drive hunger, and the resulting food-intake increase is far more pronounced than with GHRP-2 or Ipamorelin — a liability for body-composition goals and sometimes the reason it is chosen. Its GH response depends on intact endogenous GHRH signalling, so it is weaker on its own than in combination with a GHRH analogue. A controlled study in healthy men found it also increased slow-wave sleep alongside GH, ACTH, and cortisol release.
Key Benefits
- Reliable GH release in humans, especially alongside a GHRH analogue
- Marked appetite stimulation — useful where weight gain is the goal
- Increased slow-wave sleep observed in a controlled human study
- Long characterisation history and low cost
Set a goal (top of the page) to see how GHRP-6 scores against it, and what the better-evidenced alternatives are.
Category Ratings
How to Take
Common Side Effects
- Pronounced hunger
- Water retention
- Tingling or numbness in hands
- Transient rise in cortisol and prolactin
- Lethargy after dosing
Legal & Regulatory Status
Research use only. Not FDA-approved anywhere and never brought to market as a therapeutic. WADA-prohibited.
Safety and regulatory details for FDA-approved compounds are drawn from the official product label via openFDA; clinical development status reflects ClinicalTrials.gov. This information is provided for research reference, is not endorsed by the FDA, and may not be complete or current.
Research & Sources
- GHRP-6 stimulates sleep, GH, ACTH and cortisol release in normal man (PMID 7617137)
- GHRP-6 requires endogenous hypothalamic GHRH for maximal GH stimulation (PMID 9543138)
- Synthetic GHRPs — historical appraisal of the cytoprotective evidence (PMC5392015)
- Acute central ghrelin and GH secretagogues activate brain appetite centres (PMID 11751604)
Sources are selected for reliability (peer-reviewed literature, openFDA, ClinicalTrials.gov) but this is a research summary, not medical advice, and may not be exhaustive.
Prices at quality-checked sources · as of August 2026 (8 days ago)
- 5mg $51.99
- 10mg $81.91
Observed on each vendor’s public listing — see how these sources are vetted. Peptide Concierge doesn’t sell peptides and isn’t affiliated with any vendor; confirm current pricing at the source.
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