Epithalon
Pineal tetrapeptide studied for telomere biology — largely preclinical.
For research purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm these products will be used for legitimate research purposes.
About Epithalon
Epithalon (also called Epitalon or AEDG, Ala-Glu-Asp-Gly) is a synthetic tetrapeptide modeled on epithalamin, a peptide from the pineal gland. In laboratory cell cultures and rodent studies it activates telomerase, elongates telomeres, raises antioxidant enzyme activity, and has extended lifespan in mice and rats by roughly 12–24%. Human evidence is limited to two small trials — one in retinitis pigmentosa (visual-field improvement) and one reporting increased nighttime melatonin — so its telomere and longevity claims remain preclinical and are not proven in people.
Key Benefits
- Activates telomerase and elongates telomeres in cell studies (not shown in humans)
- Extended lifespan ~12–24% in rodent studies
- Increased nighttime melatonin in one small human trial
- Raises antioxidant enzyme activity in preclinical models
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Category Ratings
How to Take
Common Side Effects
- No established human safety profile (very few human studies)
- No side effects reported in a 162-patient eye-disease trial
- Injection-site reactions (typical of subcutaneous peptides)
Legal & Regulatory Status
Research use only. Not FDA-approved; no IND or NDA filed in the US. Human data limited to two small trials (retinitis pigmentosa; circadian/melatonin).
Safety and regulatory details for FDA-approved compounds are drawn from the official product label via openFDA; clinical development status reflects ClinicalTrials.gov. This information is provided for research reference, is not endorsed by the FDA, and may not be complete or current.
Research & Sources
- Epithalon induces telomerase activity & telomere elongation in human somatic cells (PMID 12937682)
- Overview of Epitalon — pineal tetrapeptide review (PMC11943447)
Sources are selected for reliability (peer-reviewed literature, openFDA, ClinicalTrials.gov) but this is a research summary, not medical advice, and may not be exhaustive.
Prices at quality-checked sources · as of August 2026 (3 weeks ago)
- 10mg $30.00
- 10mg $32.89
- 10mg $51.99
- 20mg $96.57100mg $229.36
Observed on each vendor’s public listing — see how these sources are vetted. Peptide Concierge doesn’t sell peptides and isn’t affiliated with any vendor; confirm current pricing at the source.
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