Deslorelin
Potent GnRH agonist approved only in veterinary medicine, with older human trial data.
For research purposes only. These products are not intended to diagnose, treat, cure, or prevent any disease. By purchasing, you confirm these products will be used for legitimate research purposes.
About Deslorelin
Deslorelin is a GnRH agonist substantially more potent than the natural hormone. In the United States its only FDA-cleared product is a veterinary implant — Suprelorin F, an FDA-Indexed product for adrenocortical disease in ferrets, and off-label use of that product is expressly prohibited. There is no approved human deslorelin product anywhere. It does, however, have genuine human trial history, which is unusual for a veterinary-only compound. It was used at the NIH from 1979 for central precocious puberty, and a dose-response study established that 1mcg/kg/day suppresses gonadotropins less than 4mcg/kg/day. A randomised multicentre trial gave daily intranasal deslorelin for six months with estradiol and testosterone add-back for endometriosis-related pain, with symptom scores falling from 7.4 at baseline to 2.5 at three months. Like every GnRH agonist it suppresses the axis through sustained receptor occupancy after an initial stimulatory flare — the same direction as triptorelin, not the stimulation the research market often expects from a GnRH compound.
Key Benefits
- Markedly more potent than natural GnRH
- Real human trial data in endometriosis and precocious puberty
- Long veterinary track record as a contraceptive implant
- Studied by both intranasal and subcutaneous routes
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Category Ratings
How to Take
Common Side Effects
- Initial gonadotropin and sex-steroid flare before suppression
- Hot flushes
- Bone mineral density loss with prolonged use (the reason the trials used add-back therapy)
- Reduced libido
- Headache
- Injection site or nasal irritation
Legal & Regulatory Status
No approved human product exists anywhere. In the US the only FDA-cleared deslorelin is Suprelorin F, an FDA-Indexed VETERINARY implant for adrenocortical disease in ferrets, and off-label use of it is prohibited. Human evidence comes from investigational trials, not an approval. WADA-prohibited.
Safety and regulatory details for FDA-approved compounds are drawn from the official product label via openFDA; clinical development status reflects ClinicalTrials.gov. This information is provided for research reference, is not endorsed by the FDA, and may not be complete or current.
Research & Sources
- Deslorelin with estradiol and testosterone add-back for endometriosis — randomised multicentre trial (PMC4736002)
- Effect of deslorelin dose in the treatment of central precocious puberty (PMID 1898743)
- Suprelorin (deslorelin acetate) package insert for ferrets — FDA
- GnRH/GnRH receptors in the treatment of endometriosis — class review (PMC10145781)
Sources are selected for reliability (peer-reviewed literature, openFDA, ClinicalTrials.gov) but this is a research summary, not medical advice, and may not be exhaustive.
Prices at quality-checked sources · as of August 2026 (8 days ago)
- 20mg $121.76
Observed on each vendor’s public listing — see how these sources are vetted. Peptide Concierge doesn’t sell peptides and isn’t affiliated with any vendor; confirm current pricing at the source.
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